You Position: Home > Paper
New Research Targets of Anti-TNF alpha
( views:170, downloads:16 )
- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1673-4173.2006.03.020
- Key Word:
- α肿瘤坏死因子;抗α肿瘤坏死因子,靶点
Abstract： α肿瘤坏死因子是介导炎症反应和免疫反应的细胞因子,具有广泛的生物学活性.近年来,国内外抗α肿瘤坏死因子药物的研究进展迅速.从抑制α肿瘤坏死因子、肿瘤坏死因子前体生成、拮抗已经释放的肿瘤坏死因子作用方面简要介绍了目前研究的几个主要靶点及相关药物.
- [1]Ockenfels,Schultewolter,Ockenfels,etc.The antipsoriatic agent dimethylfumarate immunomodulates T-cell cytokine secretion and inhibits cytokines of the psoriatic cytokine network[J].1998,139(3).
- [2]Lu X,Hammond JR,Feng Q,etc.Increased L-arginine uptake and inducible nitric oxide synthase activity in aortas of rats with heart failure.[J].2001,280(2).
- [3]M M, Remacle-Bonnet,F L, Garrouste,S, Heller,etc.Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways.[J].2000,60.
- [4]Andreas Eigler,Bhanu Sinha,Gunther Hartmann,etc.Taming TNF: strategies to restrain this proinflammatory cytokine[J].1997,18(10).
- [5]Dixit, V.,Mak, T. W..NF-kappaB Signaling: Many Roads Lead To Madrid[J].2002,111(5).
- [6]E, Nasatzky,Y, Rubinstein,J, Goultschin,etc.[The role of Matrix Metaloproteinases in the progression of periodontitis, and the use of specific inhibitors to these enzymes in the treatment of the periodontal disease].[J].2003,20.
- [7]Sampaio EP,Carvalho DS,Hernandez MO,etc.Management of erythema nodosum leprosum by thalidomide: thalidomide analogues inhibit M. leprae-induced TNFalpha production in vitro.[J].2002,56(1).
- [8]RAUL COIMBRA,RAFAEL DIB PORCIDES,HEIDI MELBOSTAD,etc.Nonspecific Phosphodiesterase Inhibition Attenuates Liver Injury in Acute Endotoxemia[J].2005,6(1).
- [9]Aggarwal BB,Gaur U.Regulation of proliferation, survival and apoptosis by members of the TNF superfamily.[J].2003,66(8).
- [10]Samira, Syed,Chris, Takimoto,Manuel, Hidalgo,etc.A phase I and pharmacokinetic study of Col-3 (Metastat), an oral tetracycline derivative with potent matrix metalloproteinase and antitumor properties.[J].2004,10.
- [11]Minghetti PP,Blackburn WD Jr.Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts.[J].2000,27(3).
- [12]Ramnath Nithya,Creaven Patrick J..Matrix metalloproteinase inhibitors[J].2004,6(2).
- [13]Florian Loher,Kathrin Schmall,Philipp Freytag,etc.The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice[J].2003,305(2).
- [14]Feng-hua, Yao,Xiao-di, Yao,Ji-jun, Li,etc.[Relationship between nuclear factor-kappaB activity and kidney injury in rats with postburn sepsis].[J].2005,17.
- [15]Douni Eleni,Sfikakis Petros P,Haralambous Sylva,etc.Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols[J].2003,6(1).