Paper - WANFANG MED ONLINE

You Position: Home > Paper

Mouse Models for Atopic Dermatitis

( views:288, downloads:57 )

Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY

Issue:: 1

DOI:: 10.3760/cma.j.issn.1673-4173.2006.01.012

Key Word:: 皮炎,特应性;模型,动物;DS-Nh小鼠;抗原

Abstract：特应性皮炎是一种困扰人类的慢性炎症性皮肤病,开发和确立动物模型对研究发病机制和开发药物有着重大意义.近几年,除了经典的NC/Nga鼠,人类还利用转基因和基因敲除技术及抗原建立了一系列特应性皮炎小鼠模型.这些模型的建立,为更深入地研究特应性皮炎提供了方便.

Reference

[1]H. Matsuoka,N. Maki,S. Yoshida,etc.A mouse model of the atopic eczema/dermatitis syndrome by repeated application of a crude extract of house‐dust mite Dermatophagoides farinae[J].2003,58(2).
[2]Kohara Yuki,Tanabe Kyoko,Matsuoka Kunie,etc.A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9[J].2001,53(1).
[3]Martin TR,Bhan AK,Geha RS,etc.Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.[J].1998,101(8).
[4]Hashimoto, Y.,Kaneda, Y.,Akashi, T.,etc.Persistence of Staphylococcus aureus colonization on the skin of NC/Nga mice[J].2004,35(2).
[5]Yagi R.,Nagai H.,Iigo Y.,etc.Development of Atopic Dermatitis-Like Skin Lesions in STAT6-Deficient NC\/Nga Mice[J].2002.
[6]Laouini D,Alenius H,Bryce P,etc.IL-10 is critical for Th2 responses in a murine model of allergic dermatitis.[J].2003,112(7).
[7]K Sugiura,K Hiramoto,M Shamoto,etc.Immunological cell situation in the skin of atopic model mice[J].2004,18(2).
[8]Howell MD,Hamid QA,Boguniewicz M,etc.New insights into atopic dermatitis.[J].2004,113(5).
[9]Geha RS,Yalcindag A,Laouini D,etc.Epicutaneous sensitization with superantigen induces allergic skin inflammation.[J].2003,112(5).
[10]Leung DY,Bieber T.Atopic dermatitis.[J].2003,361(9352).
[11]Ohshima H,Matsumoto K,Mizukoshi K,etc.Establishment of an atopic dermatitis-like skin model in a hairless mouse by repeated elicitation of contact hypersensitivity that enables to conduct functional analyses of the stratum corneum with various non-invasive biophysical instruments.[J].2004,10(2).
[12]Matsukura, Setsuko,Aihara, Michiko,Hirasawa, Tsutomu,etc.Effects of TNCB Sensitization in DS-Nh Mice, Serving as a Model of Atopic Dermatitis, in Comparison with NC/Nga Mice.[J].2005,136(2).
[13]Yamasaki T,Akira S,Bacon KB,etc.Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.[J].2004,16(5).
[14]Hikita, I.,Yoshioka, T.,Mizoguchi, T.,etc.Characterization of dermatitis arising spontaneously in DS-Nh mice maintained under conventional conditions: another possible model for atopic dermatitis[J].2002,30(2).
[15]Kitagaki H,Shiohara T,Fujisawa S,etc.Immediate-type hypersensitivity response followed by a late reaction is induced by repeated epicutaneous application of contact sensitizing agents in mice.[J].1995,105(6).
[16]L. CHEN,O. MARTINEZ,L. OVERBERGH,etc.Early up‐regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model[J].2004,138(3).
[17]Xu L,Robinson N,Chan LS.Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis.[J].2001,117(4).
[18]Li XM,Kleiner G,Huang CK,etc.Murine model of atopic dermatitis associated with food hypersensitivity.[J].2001,107(4).
[19]Spergel JM,Mizoguchi E,Oettgen H,etc.Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis.[J].1999,103(8).
[20]Watanabe A,Takeuchi M,Nagata M,etc.Role of the Nh (Non-hair) mutation in the development of dermatitis and hyperproduction of IgE in DS-Nh mice[J].2003,52(5).
[21]Konishi H,Tanaka M,Takeda K,etc.IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.[J].2002,99(17).
[22]Watanabe A,Takeuchi M,Nagata M,etc.Spontaneous development of dermatitis in DS-Nh mice under specific pathogen-free conditions[J].2003,52(1).