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Hedgehog信号通路与基底细胞癌
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- Author:
- No author available
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4173.2005.05.020
- Key Word:
- Hedgehog;癌,基底细胞;信号转导;治疗
Abstract： 基底细胞癌是最常见的皮肤恶性肿瘤之一.近几年的研究发现Hedgehog信号通路中Hedgehog基因、Patched基因、Smoothened基因及Gli基因等的突变使Hedgehog信号通路目的基因GLI2、WNT、HIP等的持续激活在基底细胞癌的发生发展中起关键性作用,因而调节这个通路的活性对治疗基底细胞癌有重要的指导意义.
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