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紫外线和热休克蛋白研究进展
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- Author:
- No author available
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1673-4173.2005.01.014
- Key Word:
- 紫外线;热休克蛋白
Abstract： 紫外线辐射通过多条信号传导途径和热休克转录因子诱导皮肤细胞热休克蛋白基因表达,紫外线也通过诱导热休克蛋白磷酸化、转位以发挥其适应性保护功能.热休克蛋白能抑制紫外线诱导的细胞凋亡和皮肤炎症反应.热休克蛋白在紫外线诱导的皮肤肿瘤中的不同表达表明其和皮肤肿瘤的发生、发展和预后密切相关.
- [1]Kwon, S. B.,Young, C.,Kim, D. S.,etc.Impaired repair ability of hsp70.1 KO mouse after UVB irradiation[J].2002,28(2).
- [2]Stolz W,Vogt T,Becker B,etc.Detection of differentially regulated genes in keratinocytes by cDNA array hybridization: Hsp27 and other novel players in response to artificial ultraviolet radiation.[J].2001,116(6).
- [3]Wong JW,Farboud B,Shibamoto T,etc.Ultraviolet B-mediated phosphorylation of the small heat shock protein HSP27 in human keratinocytes.[J].2000,115(3).
- [4]Franz Trautinger.Heat shock proteins in the photobiology of human skin[J].2001,63(1).
- [5]Simon M M,Reikerstorfer A,Schwarz A,etc.Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release.[J].1995.
- [6]Halimi G,Bideau C,Bellon L,etc.The expression of genes induced in melanocytes by exposure to 365-nm UVA: study by cDNA arrays and real-time quantitative RT-PCR.[J].2001,1522(2).
- [7]T. Berhane,G.M. Halliday,B. Cooke,etc.Inflammation is associated with progression of actinic keratoses to squamous cell carcinomas in humans[J].2002,146(5).
- [8]Boxman IL,Kempenaar J,de Haas E,etc.Induction of HSP27 nuclear immunoreactivity during stress is modulated by vitamin C.[J].2002,11(6).
- [9]Micksche M,Kindas Mugge I,Trautinger F,etc.Characterization of proteins associated with heat shock protein hsp27 in the squamous cell carcinoma cell line A431.[J].2002,26(1).
- [10]Lee JS,Seo JS,Park HS,etc.Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase.[J].2001,20(3).
- [11]Schwarz T,Kulms D.Independent contribution of three different pathways to ultraviolet-B-induced apoptosis.[J].2002,64(5).
- [12]C, Bayerl,B, Dorfner,B, Rzany,etc.Heat shock protein HSP 27 is expressed in all types of basal cell carcinoma in low and high risk UV exposure groups.[J].1999,9.
- [13]Gaestel M,Eyers PA,Stoiber D,etc.Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway.[J].1999,96(24).
- [14]Franklin WA,Mendez F,Kenny MK,etc.Heat shock protein 70 binds to human apurinic/apyrimidinic endonuclease and stimulates endonuclease activity at abasic sites.[J].2001,276(12).
- [15]Li G,Zhou X,Trotter MJ,etc.Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light.[J].1998,111(2).
- [16]Park KC,Eun HC,Lee JS,etc.Overexpression of HSP70 prevents ultraviolet B-induced apoptosis of a human melanoma cell line.[J].2000,292(10).
- [17]Madamanchi NR,Li S,Patterson C,etc.Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway.[J].2001,21(3).
- [18]Matsumoto T,Cao Y,Ohwatari N,etc.TGF-beta1 mediates 70-kDa heat shock protein induction due to ultraviolet irradiation in human skin fibroblasts.[J].1999,438(3).
- [19]Takehana M,Kiriyama MT,Oka M,etc.Expression of a small heat shock protein 27 (HSP27) in mouse skin tumors induced by UVB-irradiation.[J].2001,24(2).
- [20]V, Calabrese,G, Scapagnini,C, Catalano,etc.Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E.[J].2001,23.