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从噬菌体肽库中筛选抗原模拟表位的研究进展
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- Author:
- No author available
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1673-4173.2004.06.018
- Key Word:
- 肽库;抗原;分子模拟
Abstract： 大部分功能重要的抗体都可以识别抗原的构象表位,而噬菌体肽库技术最大的应用前景就是可以得到模拟抗原表位结构和化学特征的小肽分子,通过这些模拟表位不仅可以寻找、发现血清中的特异抗体,用于研究疾病的病因与发病机制以及特异性地诊断疾病;而且还可以替代抗原诱导抗体产生,达到治疗疾病的目的;同时也为新药的开发提供了新思路.
- [1]E, Ganglberger,K, Grunberger,B, Sponer,etc.Allergen mimotopes for 3-dimensional epitope search and induction of antibodies inhibiting human IgE.[J].2000,14(14).
- [2]S, Xie,M, Luca,S, Huang,etc.Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis.[J].1997,57.
- [3]Guo J,Rapoport B,McLachlan SM.Localization of the thyroid peroxidase autoantibody immunodominant region to a junctional region containing portions of the domains homologous to complement control protein and myeloperoxidase.[J].2002,277(43).
- [4]I R, Mackay,J M, Davies,M J, Rowley.Towards the pathogenesis of autoimmune liver disease.[J].1999,13(1).
- [5]WU YU ZHANG,YING WAN,DAO GUO LI,etc.A Mimotope of Pre-S2 Region of Surface Antigen of Viral Hepatitis Bscreened by Phage Display[J].2001,(3).
- [6]Myers M. A.,Davies J. M.,Tong J. C.,etc.Conformational Epitopes on the Diabetes Autoantigen GAD65 Identified by Peptide Phage Display and Molecular Modeling[J].2000.
- [7]C, Prezzi,M, Nuzzo,A, Meola,etc.Selection of antigenic and immunogenic mimics of hepatitis C virus using sera from patients.[J].1996,156.
- [8]Muyrers J,Satyamoorthy K,Meier F,etc.Mel-CAM-specific genetic suppressor elements inhibit melanoma growth and invasion through loss of gap junctional communication.[J].2001,20(34).
- [9]P, Hobby,A, Gardas,R, Radomski,etc.Identification of an immunodominant region recognized by human autoantibodies in a three-dimensional model of thyroid peroxidase.[J].2000,141.
- [10]Venzon D,Lewis MG,Chen X,etc.Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes.[J].2001,7(11).
- [11]Ferrieres, G.,Villard, S.,Pugniere, M.,etc.Affinity for the cognate monoclonal antibody of synthetic peptides derived from selection by phage display. Role of sequences flanking the binding motif[J].2000,267(6).
- [12]Franco Felici,Luisa Castagnoli,Andrea Musacchio,etc.Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector[J].1991,222(2).
- [13]Frankel SS,Stiegler G,Katinger H,etc.Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies.[J].2000,6(2).
- [14]Cerutti M,Chardes T,Roquet F,etc.Localization of the discontinuous immunodominant region recognized by human anti-thyroperoxidase autoantibodies in autoimmune thyroid diseases.[J].2003,278(11).
- [15]Heere Ress E,Breiteneder H,Scheiner O,etc.Selection of mimotopes of the cell surface adhesion molecule Mel-CAM from a random pVIII-28aa phage peptide library.[J].2002,119(4).
- [16]Schmidt R,Chou TC,Stiegler G,etc.Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection.[J].2000,6(2).
- [17]Ogert R,Shibata R,Igarashi T,etc.Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys.[J].1999,5(2).
- [18]GP Smith.Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface[J].1985,228 (4705).