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人类乳头瘤病毒感染局部细胞免疫缺陷的形成机制
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- Author:
- No author available
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1673-4173.2001.03.011
- Key Word:
- 人类乳头瘤病毒;细胞免疫
Abstract： 人类乳头瘤病毒持续感染是造成尖锐湿疣复发或宫颈癌的根本原因,而机体难以建立有效的细胞免疫,尤其是局部细胞免疫是形成人类乳头瘤病毒持续感染的基础.研究发现,人类乳头瘤病毒抗原在表皮细胞中表达甚少,且朗格汉斯细胞数量少和结构改变是造成人类乳头瘤病毒抗原提呈障碍重要原因;人类乳头瘤病毒衣壳抗原尤其是E7可以降低特异性CD4+T细胞对朗格汉斯细胞反应;细胞毒T细胞难以与人类乳头瘤病毒感染的角质形成细胞相互作用.上述是造成人类乳头瘤病毒感染难以建立有效的局部细胞免疫的重要机制.
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