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Advances in MRI study of structural and functional changes in the limbic system of Parkinson's disease with depression

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Author:: No author available

Journal Title:: Chinese Journal of Magnetic Resonance Imaging

Issue:: 12

DOI:: 10.12015/issn.1674-8034.2023.12.022

Key Word:: 帕金森病;抑郁;边缘系统;磁共振成像;磁共振结构成像;磁共振功能成像;扩散张量成像;Parkinson's disease;depression;limbic system;magnetic resonance imaging;structural magnetic resonance imaging;functional magnetic resonance imaging;diffusion tensor imaging

Abstract： Depression is one of the most common non-motor symptoms of Parkinson's disease(PD).It usually appears in the early stage of the disease,seriously affecting the quality of life and increasing the burden of the disease.Neuroimaging has found a wide range of structural and functional abnormalities in the limbic system,especially the orbitofrontal lobe,anterior cingulate gyrus,amygdala and hippocampus are closely related to the pathophysiology of PD with depression(DPD).Therefore,taking the limbic system as a starting point,this paper reviews the MRI studies related to the changes of brain structure and function in DPD patients,in order to provide new ideas for future research.

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