Abstract: Bipolar disorder is a complex mental illness characterized by intricate clinical symptoms and treatment processes.With the rapid advancement of imaging techniques,bipolar disorder manifests distinct characteristics through various resting-state functional magnetic resonance imaging(rs-fMRI)analysis methods.Utilizing rs-fMRI research can offer deeper insights into the underlying pathogenesis of bipolar disorder and establish objective imaging biomarkers for clinical diagnosis,treatment response assessment,and prognosis prediction.This approach holds the potential to guide the development of novel mood stabilizing medications.This review article focused on recent rs-fMRI research in bipolar disorders,aiming to elucidate the current advancements in neural imaging related to bipolar disorder.Furthermore,it explored potential biomarkers and avenues for early treatment response prediction.The ultimate goal is to furnish clinicians with supplementary tools for diagnosing bipolar disorder and employing imaging indicators to forecast treatment efficacy.