Abstract： Objective:To evaluate the therapeutic effect of Brucella spondylitis in the acute phase,we used dynamic contrast-enhanced MRI(DCE-MRI)combined with intravoxel incoherent motion(IVIM)quantitative parameters to observe the changes of various quantitative parameters during the disease treatment process and to select the best evaluation quantitative parameters.Materials and Methods:We prospectively enrolled 30 patients with acute phase of first confirmed Brucella spondylitis.What's more,all patients underwent routine MRI,DCE-MRI,and IVIM scans 3 months after initial diagnosis and treatment.Measurement of volume transport constant(Ktrans),extracellular volume fraction(Ve),rate constant(Kep),slow diffusion coefficient(D),fast diffusion coefficient(D*),and perfusion fraction(f)in the most significant area of the lesion(most significantly enhanced area)in a controlled study;We used SPSS 25.0 statistical software for data analysis,and all indicators showed a non-normal distribution,represented by the median±interquartile interval(M±Q).Wilcoxon rank sum test was used for statistical analysis of various quantitative parameters.Results:Ktrans values were(0.53±0.02),(0.22±0.01)min-1,Ve values were 0.45±0.01,0.48±0.03,Kep values were(1.18±0.04),(0.46±0.04)min-1,D values were(0.53±0.01)×10-3,(0.91±0.01)×10-3 mm2/s,D* values were(6.01±0.26)×10-3,(5.81±0.21)×10-3 mm2/s,and f values were 0.32±0.04,0.29±0.03,respectively,after the first diagnosis and treatment of Brucella spondylitis;The differences in Ktrans,Kep,and D values within the group were statistically significant(Z were-4.784,-4.783,and-4.786,respectively,with P＜0.01).Conclusions:The first application of DCE-MRI combined with IVIM quantitative parameters to evaluate the treatment effect of Brucella spondylitis in the acute phase provides a more scientific and objective evaluation of the microenvironmental changes from a microscopic perspective,providing a new basis for guiding clinical medication.