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Structural analysis of brain volume in patients with mild cognitive impairment at high altitude

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Author:: No author available

Journal Title:: Chinese Journal of Magnetic Resonance Imaging

Issue:: 12

DOI:: 10.12015/issn.1674-8034.2023.12.003

Key Word:: 认知障碍;轻度认知障碍;结构磁共振成像;磁共振成像;高海拔地区;cognitive impairment;mild cognitive impairment;structural magnetic resonance imaging;magnetic resonance imaging;high altitude localities

Abstract： Objective:To investigate the changes of gray matter density of native patients with mild cognitive impairment(MCI)at high altitude by structural magnetic resonance imaging(sMRI).Materials and Methods:Ninety-one native MCI patients at high altitude(MCI group)and 95 native healthy controls(HC)matched for age,gender and education(HC group)were collected for neuropsychological testing and three-dimensional T1WI magnetization prepared rapid acquisition gradient echo sequence(3D-T1WI-MPRAGE)imaging.Gray matter density was measured in different whole-brain zones using voxel morphometric measurement(VBM)to compare brain regions with significant differences in gray matter density.Results:MCI group had significantly lower gray matter density in the left hippocampus,left parahippocampal gyrus,left fusiform gyrus,and bilateral cerebellar than HC group(all P＜0.05).Conclusions:There are sMRI changes of brain in MCI patients at high altitude,this may be the structural basis for the changes in cognitive functions associated with chronic high-altitude exposure.

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