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T-lymphoblastic lymphoma complicated with Philadelphia chromosome-positive acute myeloid leukemia:report of one case and review of literature
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- Author:
- No author available
- Journal Title:
- Journal of Leukemia & Lymphoma
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1009-9921.2019.12.013
- Key Word:
- 白血病,髓样,急性;费城染色体;淋巴母细胞淋巴瘤
Abstract： 目的 探讨T淋巴母细胞淋巴瘤(T-LBL)伴费城染色体阳性急性髓系白血病(Ph+AML)的诊治方法 .方法回顾性分析靖江市人民医院收治的1例T-LBL伴Ph+AML患者的临床表现、遗传学检查、组织病理结果 、治疗经过,并进行文献复习.结果该患者为目前鲜见报道的成年人T-LBL伴Ph+AML,初期病理切片荧光原位杂交(FISH)检测提示BCR-ABL融合基因阳性.患者T-LBL确诊后予以淋巴瘤方案化疗有效,但在第3个疗程骨髓恢复期继发Ph+AML,予以羟基脲口服及白细胞单独采集,但疾病进展迅速,患者短期内死亡.结论 T-LBL伴Ph+AML非常罕见,谱系转换的机制目前尚不清楚.可表现为相继发病,来源相同.
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