Abstract： There are six main topics in acute leukemia at 56th (2014) American Society of Hematology annual meeting.The preleukemic cells were investigated in serial clinical trials.The application of High dose daunorbicin is the main topic in the area of acute myeloid leukemia (AML) chemotherapy.The application of tyrosine kinase inhibitors is the main topic in the area of target therapy of AML.The application of arsenic is the main topic in the area of acute promyelocytic leukemia (APL) treatment.AG221,an IDH2 inhibitor,and RG7388,MDM2 inhibitor,are promising target drugs for AML.CAR-T cellular immunotherapy is the hot topic in acute lymphoblastic leukemia (ALL).