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Stem cell transplantation in children
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-9921.2006.02.029
- Key Word:
- 造血干细胞移植;白血病
Abstract： 白血病是儿童时期最常见的恶性肿瘤,约占该时期所有恶性肿瘤的35%,对于传统化疗难以治愈的高危急性白血病和慢性粒细胞白血病,造血干细胞移植(HSCT)是主要的治疗手段.目前国际上推荐首选HLA匹配相关供者(MRD)的HSCT.由于80%的儿童白血病患者缺少这种供者,自体造血干细胞移植(auto-HSCT)也被选择性地应用于急性淋巴细胞白血病(ALL)和急性髓系白血病(AML)的治疗.据统计有30%～40%的患者接受了匹配的无关供者(MUD)的HSCT治疗.近年来,无关脐血移植(UDCBT)和HLA不相匹配的相关供者HSCT呈上升趋势.就近年来该方面的进展作一综述.
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