Abstract： Objective To analyze the clinical effect of TCM sequential therapy in the treatment of non-muscle-invasive bladder cancer(NMIBC)by retrospective analysis.Methods The general data of NMIBC patients diagnosed and treated in our department from January 2016 to January 2021 were retrospectively analyzed.They were divided into control group(31 cases)and traditional Chinese medicine group(24 cases)according to whether they took traditional Chinese medicine during perfusion.After TURBt,the control group was treated with bladder perfusion regularly,while the Chinese medicine group was treated with bladder perfusion and oral Chinese medicine.The adverse reactions and recurrence of the two groups were compared.Results In the control group,there were 12 cases with Grade 1 adverse reactions and 8 cases with Grade ≥2 adverse reactions,the incidence rate was 64.5％(20/31).In the traditional Chinese medicine group,there were 5 cases with Grade 1 adverse reaction and 2 cases with Grade ≥2 adverse reaction,the incidence rate was 29.2％(7/24).The incidence of adverse reactions between the two groups was statistically significant(x2=6.79,P=0.03).There was no abnormal liver and kidney function and gastrointestinal reaction in both groups.11 cases recurred in the perfusion group,the recurrence rate was 35.5％,and 2 cases in Chinese Medicine group,the recurrence rate was 8.3％,the difference between the two groups was statistically significant(x2=5.53,P=0.03).The recurrence rates of low-risk,medium-risk and high-risk in TCM group were lower than those in control group(P＜0.05).The relapse-free survival time of the two groups was 11.5(3-24)months in the perfusion group and 24(3-24)months in the perfusion+Chinese medicine group.The difference in the relapse-free survival rate between the two groups was statistically significant(P=0.048).Conclusions The sequential treatment of TCM combined with epirubicin bladder infusion can reduce the postoperative recurrence rate of NMIBC patients,reduce the adverse reactions of epirubicin infusion,and extend the recurrence free survival time of patients,with good compliance.