Abstract： Objective To investigate the effect of electroacupuncture(EA)on the expression of corticotropin-releasing hormone receptor 2(CRHR2)and NOD-like receptor family pyrin domain containing 6(NLRP6)in the duodenum of rats with function-al dyspepsia(FD).Methods A total of 40 male Sprague-Dawley rats were randomly divided into blank group,model group,and EA group,with 10 rats in each group.The rats in the model group and EA group were used to establish a model of FD by multi-factor intervention,and those in the blank group were given conventional feeding.After modeling,the rats in the EA group were given EA at Yintang,Neiguan,and Zusanli points for 30 minutes each time,once a day for 14 consecutive days.General status and body weight were observed before and after intervention;after intervention,semisolid paste was given by gavage to observe gastric emptying rate and small intestine propulsion rate;HE staining was used to observe the histomorphological chan-ges of the gastric antrum;Western blotting was used to measure the protein expression levels of CRHR2 and NLRP6 in the du-odenum;Alcian blue staining was used to observe the morphological changes of the duodenum.Results Compared with the blank group,the model group had a poor general state and significant reductions in bogy weight,gastric emptying rate,and small intestinal propulsion rate(P＜0.05);compared with the model group,the EA group had a lively and active state and significant increases in bogy weight,gastric emptying rate,and small intestinal propulsion rate(P＜0.05).The rats in the model group had loose arrangement of antral mucosa with mild edema and a small amount of lymphocyte infiltration,widened intercellular spaces between duodenal epithelial cells,a fragmented structure of the intestinal villi,and sporadic epithelial cells,while those in the EA group had a complete structure of the gastric antrum,dense arrangement of the lamina propria without significant in-flammatory response or pathological changes,and clear intercellular spaces between duodenal epithelial cells with dense arrange-ment and a complete structure.Compared with the blank group,the model group had significant reductions in the protein expression levels of CRHR2 and NLRP6 in the duodenum(P＜0.05),and compared with the model group,the EA group had significant increases in the protein expression levels of CRHR2 and NLRP6(P＜0.05).Conclusion EA can improve dyspepsia symp-toms,increase gastrointestinal motility,reduce duodenal mucosal permeability,and alleviate gastrointestinal inflammatory re-sponse in FD rats,possibly by increasing the protein expression levels of CRHR2 and NLRP6 in the duodenum.