The differences and similarities between polypoidal choroidal vasculopathy and age related macular degeneration is worthy for further investigation

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LI Xiao-xin(Department of Ophthalmology, People's Hospital, Peking University, Key Laboratory of Vision Loss and Restoration Ministry of Education, Beijing 100044 , China)
Journal Title:
Chinese Journal of Ocular Fundus Diseases
Volume 28, Issue 05, 2012
Key Word:
Choroid diseases/epidemiology; Choroid diseases/etiology; Choroid diseases/pathology; Choroid diseases/diagnosis; Editorial

Abstract: Polypoidal choroidal vasculopathy (PCV) is one of the exudative maculopathy,which is characterized by retinal pigment epithelium detachment,subretinal hemorrhages and sensory retinal detachment.The prevalence of polypoidal choroidal vasculopathy (PCV) reached 33.5% in neovascular age related macular degeneration (AMD) for Chinese population.Indocyanine green angiography showed a single or multiple focal nodular areas of hyperfluorescence arising from the choroidal circulation and currently is recognized a gold standard for diagnosis of PCV.The histopathologic findings indicated that hyalinization of choroidal vessels,like arteriosclerosis.Up to now there is no reliable evidence to demonstrate the difference in genetic study.The study of environment factor showed hypertension is associated with PCV closely than with AMD.PCV and AMD is different genotype or different phenotype as well as difference in pathogenesis need further studies.

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