Abstract： Objective To observe the clinical efficacy of intravitreal Ranibizumab on exudative agerelated macular degeneration (AMD).Methods The clinical data of 46 patients(52 eyes) with exudative AMD were analyzed retrospectively.All patients were diagnosed by examination of early treatment of diabetic retinopathy study (ETDRS) charts,color fundus photograph,fluorescein angiography (FFA) or indocyanine green angiography(ICGA) and optical coherence tomography(OCT).They received intravitreal injection of 0.05 ml (10 mg/ml) Ranibizumab,once per month for 3 months.Further injection may be required if the monthly follow-up indicated.A total of 52 eyes received 214 times of injections,each eye received 2-6 injections (mean 4.12).The Follow-up duration was 12 months.Vision acuity,fovea thickness and CNV leakage before and after treatment were analyzed.Results At the 12th month after treatment,the mean letter of ETDRS charts was 37.80 (11.40 letters more that pre-treatment index,P<0.01).FFA and (or) ICGA showed complete closures choroidal neovascularization (CNV) in 11 eyes (21.20%),partial closures in:34 eyes (65.40%),no change in four eyes (7.70%),lesion growth in two eyes(3.80%)and new lesion in one eye (1.90%).OCT indicated the average of fovea thickness was 187.50 μm (122.80 μm less than the pre-treatment index,P<0.01).Conclusion Intravitreal injection of Ranibizumab for exudative AMD according to this therapeutic schedule was well tolerated,with an improvement in visual acuity,FFA or ICGA and OCT.