Abstract： Objective To evaluate the clinical features.risk factors and treatment outcomes ofendogenous candida albieans endophthalmitis.Methods The clinical data of 11 patients(18 eyes)withvitreous specimen culture-proven endogenous candida endophthalmitis were retrospective reviewed,including risk factors,clinical features and therapeutic methods and outcomes.Results There were 4males and 7 females patients,aged from 19 to 72 years with a mean age of(41.61±9.76)years.Sevenpatients had bilateral endophthalmitis.They had histories of induced abortion(2 patients),intravenoustransfusion(3 patients),colon cancer surgery(1 patient),chemotherapy after surgery of malignantlymphoma of colon(1 patient),renal transplantation(1 patient),acute necrotic pancreatitis surgery(1patient)and diabetes(1 patient).One patient has no special medical history.All patients had no historyof ocular trauma or intraocular surgery.The major complaints included blurred vision,metamorphopsiaand floaters.It taken an average of(15.23±8.70)days(3-38 days)for patients to go to the hospital aftergetting those symptoms.The main clinical manifestations included pre-or sub-retinal white exudates andvitreous inflammations.In 18 eyes,11 received vitreous surgery,and the other 7 were treated byintravitreal administration of anti-fungal drugs.Ten patients also underwent systemic anti-fungal therapy.The candida endophthalmitis was cured for 10/11 patients and most of them with increased visual acuity.Conclusions Endogenous candida albicans endophthalmitis iS characterized by pre-or sub-retinal whiteexudates and vitreous inflammations.Non-standard intravenous transfusion,induced abortion andmalignancy are its major risk factors.Pars plana vitrectomy or intravitreal delivery of anti-fungal drugs cancure this disease.