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Primary study of photodynamic therapy for choroidal neovascularization caused by age-related macular degeneration
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1003-9279.2000.04.012
- Key Word:
- 黄斑变性;盲/病因学;黄斑变性/治疗;光动力疗法
Abstract： 目的 观察单次光动力治疗(photodynamic therapy,PDT)对渗出型老年性黄斑变性(age-related macular degeneration,AMD)脉络膜新生血管(choroidal neovascularization,CNV)的近期治疗效果.方法 回顾分析经荧光素眼底血管造影(fundus fluorescein angiography, FFA)、吲哚青绿脉络膜血管造影(indocyanine green angiography, ICGA)以及光学相干断层扫描(optic coherence tomography,OCT)检查确诊的5例渗出型AMD患者的7只患眼行PDT治疗前及治疗后随访观察1周和1个月时的临床资料,主要以视力、FFA及(或)ICGA、OCT的改变为观察指标,评价PDT对渗出型AMD的治疗效果.结果 7只患眼在治疗后1个月视力均无下降.治疗后1周时除1只眼在ICGA后期仍可观察到CNV有轻微渗漏外,其余6只眼FFA及(或)ICGA均显示CNV渗漏停止;OCT检查显示CNV有不同程度缩小,CNV周围视网膜脉络膜水肿及神经上皮脱离明显好转.但在治疗后1个月时观察到有2只眼在原渗漏病灶处又有渗漏灶出现.结论 PDT 治疗可以在短期内封闭AMD的CNV,使其停止渗漏,且不影响视力.
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