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Fetal nucleated erythroblast and erythrocyte immune adhesive function in maternal blood in preeclampsia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1007-9408.2011.07.005
- Key Word:
- No keyword available
Abstract： @@ 子痫前期(preeclampsia)是妊娠期特有的严重并发症,是影响孕产妇和围产儿发病率和死亡率的主要原因之一.研究发现,子痫前期的发生与胎儿细胞、滋养层细胞、炎性合体滋养层细胞穿透胎盘,向母体输送与释放增加有关[1-3],尤其是目前用于无创性产前诊断的胎儿有核红细胞(fetal nucleated red blood cells,FNRBC)的穿透渗漏成为研究热点,报道认为子痫前期孕妇血循环中FNRBC数量增加[4-6].人体内部起免疫功能的细胞主要有红细胞和白细胞,而红细胞清除免疫复合物的作用比普遍认为具有免疫和防御功能的白细胞高.研究认为子痫前期的发生与孕妇自身免疫系统病理损伤和紊乱有关[7-9],目前国内尚未检索到有关该类孕妇母血FNRBC数量变化及其与红细胞免疫黏附功能相关性分析的报道.本研究对此进行了探讨,期望为阐明重度子痫前期发病的可能机制提供依据,现将结果报告如下.
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