Abstract： Objective To explore the relationship of lipid metabolism with neonatal body index in mothers with abnormal glucose metabolism during pregnancy and how lipid metabolism inflenees fetal growth. Methods This study recruited 150 mothers and their babies admitted in our hospital from November 2006 to February 2007 including 73 eases of abnormal glucose metabolism with good glycemic control and 77 with normal glucose tolerance. The babies were divided into two groups:LGA (n=25) and AGA (n=125). Clinical data and serum lipid profiles(HDL,LDL,TG,TC)in cord blood were obtained and analyzed Results No significant difference in cord blood levels of HDL, LDL, TC were found between LGA and AGA group, however, with mild elevated TG level in LGA group [(0. 23±0. 16) mmol/L vs (0. 14±0.08)mmol/L,P<0. 05]. In newborns of mothers with abnormal glucose metabolism, the birth weight of LGA infanta was positively correlated with cord blood TG level(r= 0. 625, P<0. 05), but not with the HDL, LDL or TC level. In newborns of mothers with normal glucose tolerance, the body index of LGA infants was not correlated with cord blood lipid profiles. Risk factors of delivering LGA infants were:weight gain during pregnancy≥18 kg, cord blood TG>0. 11 mmol/L. Conclusions LGA infants have a higher level of cord blood TG than AGA which implies that cord blood TG may play a role in fetal overgrowth in mothers with abnormal glucose metabolism. LGAs are more likely to occur when cord blood TG＞0. 11 mmol/L.