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Expression and significance of the multidrug resistance-associated proteins in placenta
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1007-9408.2007.06.004
- Key Word:
- 孕龄;胎盘;多药耐药相关蛋白质类;免疫组织化学
Abstract： 目的 探讨多药耐药相关蛋白(mutidrug resistance-associated protein,MRP)1、MRP3在不同孕龄胎盘中的表达情况,以阐明二者在胎盘中的生理功能.方法 选取早孕期绒毛及中、晚孕期胎盘标本各40例、20例、30例.免疫组化法检测MRP1、MRP3的表达.结果 MRP1主要定位于各期绒毛的合体滋养细胞的胞浆和胞膜;随妊娠进展,阳性表达逐渐下降,MRP3定位于各期绒毛的合体滋养细胞的胞浆和胞膜;随妊娠进展,阳性表达逐渐上升,在早、中、晚孕绒毛中MRP1阳性表达率分别为100%、90%、60%,MRP3分别为40%、80%、93%. 结论 MRP1可能参与胎盘的形成过程.MRP3可能有排除胎儿代谢终产物的生理功能,对胎儿有保护作用.
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