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Earlier predictive value of plasma soluble HLA-G for pre-eclampsia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1007-9408.2007.05.003
- Key Word:
- 先兆子(癎);HLA抗原;组织相容性抗原I类;早期诊断
Abstract： 目的 探讨血浆中可溶性人类白细胞抗原-G(soluble HLA-G,sHLA-G)对子(癎)前期的早期预测价值.方法 采用前瞻性研究方法,在妊娠早期收集120例最初正常妊娠妇女的血浆样本,同时对其妊娠中期及晚期的血浆样本进行纵向收集,并且随访其妊娠结局.运用双抗体夹心酶联免疫吸附(ELISA)检测血浆sHLA-G水平. 结果 120例在早孕期最初正常的妇女中有19例随后发生子(癎)前期,101例妊娠结局正常.随妊娠进展,子(癎)前期组与正常妊娠组的血浆sHLA-G水平均有下降趋势,但无统计学意义(P＞0.05).妊娠早期、中期、晚期子(癎)前期组血浆sHLA-G水平[分别为(1.25+0.02)mg/ml、(1.11±0.05)mg/ml、(0.98±0.03)mg/m1]均显著低于正常妊娠组[分别为(1.95±0.03)mg/ml、(1.90±0.02)mg/ml、(1.86±0.05)mg/ml,P均＜0.05].早孕期血浆sHLA-G预测子(癎)前期的ROC曲线下面积为0.875.以sHLA-G等于1.57mg/ml为切点预测子痴前期的敏感性、特异性、阳性预测值、阴性预测值及Kappa指数分别为95%、84%、70%、97%、0.645.结论 妊娠期血浆sHLA-G水平的降低与子(癎)前期的发生有密切关系.妊娠早期检测血浆sHLA-G水平将有助于早期预测子(癎)前期.
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