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Relationship between expression of hepatocyte growth factor(HGF) and apoptosis of trophoblasts in HD-CP
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1007-9408.2006.04.005
- Key Word:
- 肝细胞生长因子;妊娠并发症,心血管;高血压;滋养层;细胞凋亡
Abstract： 目的探讨肝细胞生长因子(hepatocyte growth factor,HGF)在妊娠期高血压疾病(hypertensive disorder complicating pregnancy,HDCP)妇女胎盘组织中的表达及对胎盘绒毛滋养细胞凋亡的影响.方法选取不同程度HDCP晚孕孕妇34例及正常晚孕孕妇30例.采用逆转录聚合酶链反应(RT-PCR)的方法检测其胎盘组织中HGF和Fas mRNA表达量.结果(1)与对照组(0.67±0.19)相比,妊娠期高血压组HGF mRNA表达无显著差异(0.65±0.06,P＞0.05),轻度子癎前期、重度子癎前期和子癎组HGF mRNA表达显著降低(0.43±0.12,0.38±0.09和0.19±0.17,P＜0.05),且随病情加重,表达强度逐渐降低;(2)轻度子癎前期、重度子癎前期和子癎组FasmRNA与对照组相比,表达显著升高(1.58±0.26,2.96±0.14,5.98±1.17和1.01±0.36,P＜0.05),且随病情加重,表达强度逐渐增加;(3)胎盘组织中HGF和Fas表达呈负相关(r=-0.618,P＜0.05).结论胎盘间质细胞表达的HGF具有抑制由Fas介导的滋养细胞凋亡作用.患HDCP孕妇胎盘HGF表达下降可能是引起滋养细胞凋亡的原因之一.
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