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Preterm birth prediction with fetal fibronectin in pregnant women with preterm labor
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1007-9408.2006.01.002
- Key Word:
- 纤维连接蛋白类;超声检查,产前;子宫颈;分娩,早产;预测
Abstract： 目的研究胎儿纤维连接蛋白(fetal fibronectin,fFN)对先兆早产孕妇发生早产的预测价值,及与宫颈长度联合应用时对早产的预测意义.方法联合国内三家医院对有先兆早产症状的孕妇进行阴道后穹窿分泌物中fFN的测定及宫颈的超声检测,追踪这些孕妇的妊娠结局.结果(1)共检测122例先兆早产孕妇,75例fFN阳性,阳性率为61.5%.(2)阳性孕妇中7 d内、14 d内、37周前分娩率分别为22.7%(17/75)、41.3%(31/75)、65.3%(49/75);阴性孕妇则分别为0%(0/47)、0%(0/47)、12.8%(6/47).对于7 d内、14 d内和37周内分娩的阴性预测值分别为100%、100%和87.2%.(3)50例孕妇同时进行了宫颈长度的测量.以宫颈长度≤26mm为异常.50例中fFN(+)和宫颈长度同时异常者7 d内、14 d内、37周前分娩率分别为13.3%(2/15)、40.0%(6/15)、93.3%(14/15),均显著高于fFN(+)而宫颈长度正常的孕妇.宫颈长度异常而fFN阴性者中无一例14 d内分娩.二者同时异常预测先兆早产孕妇发生早产的敏感性为70%,特异性为97.2%,阳性预测值为93.3%,阴性预测值为85.4%.结论(1)在先兆早产孕妇中阴道后穹窿分泌物fFN阳性对先兆早产孕妇发生早产有一定的预测意义,阴性预测短期内不发生早产的价值较大.(2)fFN测定与宫颈长度联合应用可以提高37周前早产阳性预测结果,但对短期内发生早产的预测意义不大.
- [1]Lockwood, C.J.,Senyei, A.E..Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery.[J].1991,325(10).
- [2]G M, Joffe,D, Jacques,R, Bemis-Heys,etc.Impact of the fetal fibronectin assay on admissions for preterm labor.[J].1999,180.
- [3]Kaider A,Leitich H.Fetal fibronectin-how useful is it in the prediction of preterm birth?[J].2003,110(Suppl.20).
- [4]Iams JD.Prediction and early detection of preterm labor.[J].2003,101(2).
- [5]Hauth JC,Goldenberg RL,Andrews WW.Intrauterine infection and preterm delivery.[J].2000,342(20).
- [6]A M, Peaceman,W W, Andrews,J M, Thorp,etc.Fetal fibronectin as a predictor of preterm birth in patients with symptoms: a multicenter trial.[J].1997,177(1).