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Relation of serum leptin to birth weight and insulin in preterm and term neonates
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1007-9408.2005.05.016
- Key Word:
- 瘦素;胰岛素;出生体重;婴儿,早产;婴儿,新生
Abstract： 目的研究早产和足月新生儿血清瘦素与出生体重及胰岛素关系, 探讨在早产和足月新生儿中是否存在脂肪-胰岛素内分泌轴. 方法共收集264例早产和足月新生儿, 按胎龄进行分组, 并进行出生测量,于生后第3天采血做餐前血糖、胰岛素及瘦素检查. 结果足月儿血清瘦素浓度显著高于早产儿, 瘦素浓度与胎龄的关系按非线性模式增加,胎龄34周以后,瘦素浓度增加明显加快.在>32周的新生儿中,血清瘦素浓度与出生体重及胰岛素呈正相关关系(r=0.240, 0.227, P<0.05),在胎龄≥37周的新生儿中,瘦素不仅与出生体重及胰岛素呈正相关(r=0.198, 0.253, P<0.05),还与胰岛素/血糖呈正相关(r=0.206, P<0.05),在<32周的新生儿中,未发现上述关系. 结论胎龄>32周的新生儿体内可能已开始存在脂肪-胰岛素内分泌轴.
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