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Expression and clinical significance of TGFβ1, TGFβRⅠ , TGFβRⅡ in placenta of pregnancy induced hypertention

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PERINATAL MEDICINE
Issue:
2
DOI:
10.3760/cma.j.issn.1007-9408.2005.02.004
Key Word:
转化生长因子β;受体,转化生长因子β;妊娠并发症,心血管;高血压;免疫组织化学

Abstract: 目的探讨转化生长因子β1(transforming growthfactor-beta1,TGFβ1)及其受体(TGFbeta receptor,typeⅠ and typeⅡ,TGFβRⅠ,TGFβRⅡ)在妊娠高血压综合征(妊高征)患者胎盘组织中的表达及其临床意义.方法采用免疫组化SABC法检测64例妊高征患者(轻度21例,中度20例,重度23例)胎盘组织中TGFβ1、TGFβRⅠ、TGFβRⅡ的表达,20例正常孕妇为对照组.结果妊高征组胎盘绒毛滋养细胞及蜕膜细胞TGFβ1,TGFβRⅠ,TGFβRⅡ的阳性表达率均明显高于对照组(TGFβ1:70.31%和35.00%,P<0.01;TGFβR Ⅰ:76.56%和50.00%,P<0.05;TGFβRⅡ:79.69%和45.00%,P<0.01).妊高征组轻、中、重度患者TGFβ1、TGFβRⅠ和TGFβRⅡ表达的阳性率分别为:TGFβ1:52.38%、75.00%和82.61%;TGFβRⅠ:57.14%、85.00%和86.96%;TGFβRⅡ:61.90%、85.00%和91.30%,并随病情程度增加而升高.TGFβ1的表达与胎盘重量及新生儿体重呈负相关.结论胎盘TGFβ1及TGFβRⅠ、TGFβRⅡ表达异常引起滋养细胞浸润不足,可能是妊高征的发病因素之一.

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