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Relationship between fetal growth and levels of leptin and its receptor in maternal, umbilical plasma and placenta
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1007-9408.2004.06.002
- Key Word:
- 瘦素;载体蛋白质类;胎儿生长迟缓
Abstract： 目的探讨母血、脐血和胎盘瘦素及瘦素受体表达与胎儿生长发育的关系.方法采用ELISA法和逆转录定量聚合酶链反应检测23例小于胎龄儿(SGA)和44例适于胎龄儿(AGA)母血、脐血瘦素和可溶性瘦素受体(sOB-R)浓度,胎盘组织瘦素mRNA和瘦素受体(OB-R)mRNA表达水平.结果SGA组和AGA组母血瘦素浓度分别为(33.80±14.05)μg/L和(27.01±14.81)μg/L(P=0.089);母血sOB-R浓度分别为(25.56±10.78)μg/L和(26.61±9.69)μg/L(P=0.701);脐血瘦素浓度分别为(6.79±4.59)μg/L和(16.30±11.61)μg/L(P=0.000);脐血sOB-R浓度分别为(18.24±6.02)μg/L和(13.80±4.39)μg/L(P=0.002);胎盘组织瘦素mRNA表达分别为0.77±0.13和0.99±0.29(P=0.002);OB-R mRNA表达分别为0.56±0.21和1.07±0.27(P=0.000).脐血瘦素、胎盘瘦素和OB-R mRNA表达水平分别与新生儿体重、身高、体脂、头围呈正相关,脐血sOB-R分别与上述新生儿指标呈负相关.结论脐血瘦素浓度降低和胎盘瘦素、OB-R受体表达低下与胎儿生长受限密切相关,脐血瘦素可能通过与不同剪接体的受体结合实现对胎儿生长发育的调控作用.
- [1]韩树萍,郭锡熔,陈荣华,等.新生儿脐血瘦素水平测定及相关因素分析[J].2000,(6).
- [2]刘彤,尚涛,芮广海.瘦素在胎盘组织中的表达及其与新生儿体重的关系[J].2001,(5).
- [3]Lammert A,Seidel B,Bottner A,etc.Circulating Soluble Leptin Receptor and Free Leptin Index during Childhood, Puberty, and Adolescence.[J].2002,87(10).
- [4]L, Gómez,A, Carrascosa,D, Yeste,etc.Leptin values in placental cord blood of human newborns with normal intrauterine growth after 30-42 weeks of gestation.[J].1999,51.
- [5]S, Schulz,C, H?ckel,W, Weise.Hormonal regulation of neonatal weight: placental leptin and leptin receptors.[J].2000,107(12).
- [6]Jaquet D,Leger J,Levy-Marchal C,etc.Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations.[J].1998,83(4).
- [7]Rowan CG,Villa P,Agnello D,etc.Leptin causes body weight loss in the absence of in vivo activities typical of cytokines of the IL-6 family.[J].1998,275(3 Pt.2).