You Position: Home > Paper
Fetal cardiac hemodynamic changes and its relationship with chromosomal abnormalities in the first trimester
( views:286, downloads:36 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1007-9408.2004.06.001
- Key Word:
- 胎儿心脏;超声检查,产前;血流动力学;妊娠初期;染色体畸形
Abstract： 目的了解人类妊娠早期胎心血流动力学变化的规律,初步筛查出与染色体畸形可能相关的血流讯号.方法采用经阴道二维+多普勒超声技术对172例妊娠早期正常孕妇的胚胎/胎儿心脏进行研究,得出正常参数;随之对1022例行人工流产的孕妇胚胎/胎儿心脏进行探查,总结异常变化并进行绒毛染色体分析.结果(1)妊娠早期胎心血流动力学的变化:妊娠7周以前,原始心搏引起的多普勒讯号表现为单一峰值;妊娠7周后,可观察到流入流出道方向相反的血流,通过流入道的血流流速波形为单峰;妊娠第9周起,通过流入道的血流流速波形开始呈现双峰,e峰出现;胎心率早期随胎龄增加而增快,第10周时最快,之后则有所减慢.(2)观察到27例胎儿心脏血流动力学异常,其中9例核型分析结果异常(3例心动过缓,4例半月瓣返流,2例房室瓣返流).结论妊娠早期胎儿心脏可用高频率经阴道超声进行观察,其血流动力学变化存在时相性特征.早期超声探及心动过缓、出现瓣膜返流讯号的胚胎/胎儿与染色体畸形有一定相关性.
- [1]A W, Liao,R, Snijders,L, Geerts,etc.Fetal heart rate in chromosomally abnormal fetuses.[J].2000,16.
- [2]Maria L. Respondek,Michael Kammermeier,Abraham Ludomirsky,etc.The prevalence and clinical significance of fetal tricuspid valve regurgitation with normal heart anatomy[J].1994,171(5).
- [3]Y H, Gui,K K, Linask,P, Khowsathit,etc.Doppler echocardiography of normal and abnormal embryonic mouse heart.[J].1996,40.
- [4]杜传书,刘祖洞主编.医学遗传学[M].1983.
- [5]W.A. Lutin,M.R. Brumund,C. Jones,etc.Hemodynamic Abnormalities in Fetuses with Congenital Heart Disease[J].1999,20(6).
- [6]M C, Leiva,J E, Tolosa,C N, Binotto,etc.Fetal cardiac development and hemodynamics in the first trimester.[J].1999,14.
- [7]Jon Hyett,Gonzalo Moscoso,Kypros Nicolaides.Abnormalities of the heart and great arteries in first trimester chromosomally abnormal fetuses[J].1997,69(2).