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Expression of angiotensin Ⅱ type 1 receptor and angiotensinogen in preeclamptic placenta
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1007-9408.2004.05.004
- Key Word:
- 妊娠并发症,心血管;高血压;受体,血管紧张素;血管紧张素原
Abstract： 目的探讨血管紧张素Ⅱ1型受体(angiotensinⅡtype 1 receptor, AT1R)和血管紧张素原(angiotensinogen, AGT)在妊娠高血压综合征(妊高征)患者胎盘组织中表达的变化及其在妊高征发病中的意义. 方法采用免疫组织化学染色法(免疫组化)和逆转录聚合酶链反应法(RT-PCR),检测20例中、重度妊高征患者(妊高征组)和15例正常妊娠妇女(正常组)的胎盘组织AT1R水平及AT1R mRNA和AGT mRNA的表达. 结果 (1)AT1R主要定位于胎盘绒毛滋养细胞、血管内皮细胞及血管平滑肌细胞.(2)免疫组化定量灰度分析,妊高征组胎盘组织AT1R阳性表达(112.43±11.75)显著强于正常组(170.47±10.59)(P<0.01).(3)妊高征组胎盘组织AT1R mRNA的表达水平(0.96±0.20)高于正常组(0.56±0.14)(P<0.01).妊高征组胎盘组织AGT mRNA的表达水平(1.08±0.22)亦显著高于正常组(0.60±0.12)(P<0.01). 结论在妊高征患者胎盘组织中,AT1R和AGT表达均有明显增加,说明胎盘组织局部肾素-血管紧张素系统与妊高征发病有相关性.
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