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The role of autoantibodies against angiotensinⅡ type 1-receptor in the pathogenesis in preeclampsia

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PERINATAL MEDICINE
Issue:
4
DOI:
10.3760/cma.j.issn.1007-9408.2004.04.004
Key Word:
妊娠并发症,心血管;高血压;自身抗体;受体,血管紧张素

Abstract: 目的探讨抗血管紧张素Ⅱ受体1型(angiotensinⅡtype 1-receptor, ATR-1)自身抗体在妊高征发病中的作用. 方法以合成的ATR-1多肽片段为抗原,采用酶联免疫吸附法检测46例妊高征患者和 40例正常孕妇血清抗ATR-1自身抗体和血浆中血管紧张素Ⅱ的浓度. 结果妊高征抗ATR-1自身抗体的阳性率为63.0%(29/46),明显高于正常孕妇7.5%(3/40)(P<0.01).妊高征组血浆血管紧张素Ⅱ水平[(92.54±37.22) pmol/L]亦明显高于血压正常组[(25.75±12.33) pmol/L,P<0.01]. 结论妊高征患者合并血管紧张素Ⅱ浓度升高,其血清中存在抗ATR-1的自身抗体,该抗体可能在妊高征的发病机制中起重要作用.

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