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Clinical study of interrupting HBV intrauterine infection by immunization of pregnant women and infant
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1007-9408.2004.01.002
- Key Word:
- 肝炎病毒,乙型;疾病传播,垂直;免疫球蛋白类,静脉内;肝炎疫苗,乙型;接种
Abstract： 目的探讨母婴联合免疫阻断乙型肝炎病毒宫内传播的效果. 方法将216例乙肝表面抗原阳性孕妇分组,母婴联合组126例,孕妇自孕28周起注射人乙型肝炎免疫球蛋白(HBIG) 200 IU,新生儿于0、15 d各注射HBIG 200 IU,然后于1、2、7月龄各接种基因乙肝疫苗(HBVac )20 μg.对照组90例,只对新生儿进行免疫.母儿血清检测采用美国Abbott酶联免疫试剂测定,随访1年. 结果联合免疫组婴儿宫内感染率低于对照(19.51% 与35.56%),慢性HBV感染率由13.33%降为3.97%,P均<0.05;联合免疫组及对照组新生儿出生时抗HBs检出率(80.95%与 0)及1岁时保护性抗体产生率(96.03%与86.67%)均明显高于对照组,P均<0.05. 结论孕妇及婴儿联合免疫可有效预防宫内感染且明显提高宫内感染阻断效果,减少慢性HBV感染率.
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