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The Relation Between Hypocarbia and Periventricular Leukomalacia in Preterm Infants
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1007-9408.2003.06.003
- Key Word:
- 婴儿,早产;白质软化病,脑室周围;呼吸,人工;低碳酸血症
Abstract： 目的探讨早产儿脑室周围白质软化(PVL)与机械通气下低碳酸血症的关系. 方法对合并PVL和未合并PVL的胎龄26～32周早产儿各25例,进行对照研究.对生后前3 d机械通气参数和血气指标进行比较. 结果两组生后前3 d机械通气参数吸气峰压、呼气末正压、平均气道压、呼吸频率差异均无显著性.PVL组和对照组低氧血症的持续时间分别为(3.7±1.1)和(4.1±1.3)h,两组差异无显著性(P>0.05).PVL组和对照组生后72 h最低PaCO2分别为(23.0±1.2) mm Hg (1 mm Hg=0.133 kPa) 和(31.0±7.6)mm Hg;低碳酸血症的持续时间分别为(26.3±7.8)和(1.7±0.4)h;两组差异有非常显著性(P<0.01).最低PaCO2≤25 mm Hg时,病例对照研究的比值比(OR)为16.6(95%,可信限为4.1～67.4,P<0.01). 结论机械通气下的低碳酸血症与早产儿PVL密切相关.生后72 h内PaCO2低于25 mm Hg,早产儿发生PVL的危险性显著增高.
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