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The Influence of Antepartum Multiple and Single Course Glucocorticoid Treatment on Preterm Birth Infants
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1007-9408.2003.03.005
- Key Word:
- 糖皮质激素类;婴儿,早产;婴儿,早产,疾病;呼吸窘迫综合征;综合分析
Abstract： 目的综合评价产前多疗程与产前单疗程肾上腺糖皮质激素治疗对早产儿的有效性和安全性. 方法对满足条件的7篇有关产前肾上腺糖皮质激素治疗对早产儿影响的队列研究进行Meta分析. 结果产前多疗程肾上腺糖皮质激素治疗可降低早产儿动脉导管未闭(PDA)的发病率(OR=0.51,95%CI 0.49～0.54), 有使早产儿呼吸窘迫综合征(RDS)发生率降低的趋势 (OR=0.72,95%CI 0.49～1.07).但可增加早产儿败血症的发生率(OR=1.62,95%CI 1.07～2.44), 且不能降低早产儿颅内出血(ICH)(OR=0.65,95%CI 0.37～1.15)、坏死性小肠结肠炎(NEC)(OR=1.30,95%CI 0.79～2.12)和慢性肺疾病(CLD)(OR=0.94,95%CI 0.59～1.49)的发生率及病死率(OR=1.07,95%CI 0.42～2.75),也不能使早产儿出生后肺表面活性物质(PS)的应用减少(OR=0.86,95%CI 0.48～1.55). 结论无法根据现有的Meta分析结果证明产前多疗程肾上腺糖皮质激素治疗比产前单疗程肾上腺糖皮质激素治疗更有效和危险性更小.
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