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The Effects of Anticoagulant Proteins Defect in Maternal Plasma on Spontaneous Abortion
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1007-9408.2003.01.005
- Key Word:
- 蛋白S缺乏;蛋白C缺乏;活化蛋白C抵抗;抗凝血酶Ⅲ缺乏;妊娠结局;流产,自然
Abstract： 目的探讨抗凝蛋白缺陷在不明原因自然流产妇女发病中的作用机制. 方法 1999年5月至2000年4月北京协和医院妇产科诊治的不明原因自然流产患者57例.选择50例既往有过正常妊娠分娩史的患者蛋白C抵抗(APC-R).并对APC-R阳性的患者进行FV Leiden基因变异测定. 结果研究组PS、PC及AT-Ⅲ缺陷的发生率分别为21.1%、1.8%及8.8%,APC-R阳性的发生率为22.8%.而对照组PS缺陷的发生率为4.0%;无PC及AT-Ⅲ缺陷的发生;APC-R阳性的发生率为6.0%.所有APC-R阳性患者FV Leiden基因均无变异. 结论抗凝蛋白缺陷可能与自然流产的发生,特别是晚期流产的发生相关联.
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