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Study on Relationship between the sharing of HLA Gene Couples with Gestational Diabetes Mellitus

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PERINATAL MEDICINE
Issue:
4
DOI:
10.3760/cma.j.issn.1007-9408.2002.04.001
Key Word:
糖尿病,妊娠;HLA-DR抗原;等位基因

Abstract: 目的将人类白细胞抗原(human leukocyte antigen,HLA)Ⅱ类基因作为妊娠期糖尿病(gestational diabetes mellitus,GDM)的候选基因之一,探讨GDM患者夫妇HLA-DRB等位基因共享性与GDM发病机制的关系.方法GDM孕妇及其配偶30对为研究对象,随机选择与研究对象同期入院的同年龄组正常健康孕妇及其配偶40对作为对照组,所有产妇均为单胎初产.采集肘静脉血5 m1,酚/氯仿抽提法提取基因组DNA,PCR-SSP法进行HLA-DRB基因分型.结果在GDM组中,共享1对及1对以上HLA-DRB1等位基因的夫妇占总数的33.33%,高于正常妊娠组的12.50%,差异有显著性[P<0.05,相对危险度(RR)=2.30].剔除两组相同的共享等位基因的校正分析也显示GDM组夫妇共享HLA-DRB1等位基因明显高于正常妊娠组(16.67%与0,P<0.05,RR=1.20),且GDM组夫妇共享的等位基因SSCP带型一致,未见亚型.GDM组与正常妊娠组相比,夫妇对HLA-DRB3、B4、B5等位基因的共享性无显著差异(P>0.05).结论夫妇共享HLA-DRB1基因时,发生GDM的风险增大,提示胎儿-胎盘单位在GDM发病中具有一定作用.

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