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Study on the Level of Interleukin-6 Mrna of Placentae and Amnion in Severe Pregnancy-Induced Hypertension
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1007-9408.2002.03.004
- Key Word:
- 白细胞介素6;妊娠并发症,心血管;高血压;胎儿生长受限
Abstract： 目的从免疫学角度了解重度妊娠高血压综合征(简称妊高征)和胎儿生长受限(fetal growth retardation,FGR)时胎盘和羊膜白细胞介素6(IL-6)的水平. 方法采用逆转录聚合酶链反应(RT-PCR)技术检测重度妊高征患者胎盘与羊膜IL-6 mRNA的表达. 结果重度妊高征患者胎盘IL-6 mRNA相对含量为0.71±0.07,羊膜IL-6 mRNA相对含量为0.81±0.12, 均较正常妊娠时为低(P<0.01, P<0.05).合并FGR组胎盘IL-6 mRNA相对含量为0.68±0.04,羊膜IL-6 mRNA相对含量为0.76±0.07,均较不合并FGR组为低,但无统计学差异(P>0.05). 结论作为免疫因子的IL-6可能参与了重度妊高征的免疫损伤过程,胎盘或羊膜中IL-6含量降低可能是导致FGR发生的原因.
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