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Study on Epidermal Growth Factor in Plasma and Its Rec eptor in Placenta in Severe Pregnancy Induced Hypertension
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1007-9408.2002.01.005
- Key Word:
- 妊娠并发症,心血管;高血压;胎儿生长迟缓;表皮生长 因子;受体,表皮生长因子
Abstract： 目的研究孕晚期重度妊娠高血压综合征(妊高征)并发及未并发胎儿生长受限(FGR)者的血浆表皮生长因子(EGF)水平、胎盘组织EGF受体(EGFR)表达情况,探讨EGF与妊高征的关系、EGF在妊高征及FGR发生中的作用、EGF对妊高征胎儿生长发育的影响,为妊高征及FGR的病因研究及治疗提供依据. 方法血浆EGF及血清胎盘生乳素(HPL)采用放射免疫分析法测定,胎盘组织EGFR 采用免疫组织化学方法测定. 结果 (1)血浆EGF浓度,重度妊高征组为 (96±46) ng/L,明显低于对照组(144±36)ng/L,(t=4.169,P<0.01).重度妊高征并发FGR组为(89±37)ng/L,重度妊高征未并发FGR组为(101±54)ng/L,均明显低于对照组,D unnett t=3.94、3.20,P<0.01,但此二者之间差异无显著性,(t=0.792,P>0.05). (2)血清HPL与血浆EGF呈正相关.(3)胎盘EGFR染色情况.重度妊高征胎盘EGFR的表达比对照组强,妊高征组染色通光度为114±8,对照组为125±9(t=4.74,P<0.01),且无论妊高征并发或未并发FGR,其胎盘EGFR的表达都比对照组强,FGR组为115±8,NFGR组为11 4±7,Dunnettt值分别为3.64、4.35,P值均<0.01.但在妊高征者FGR组与NFGR组之间差异无显著性,(t=0.55,P>0.05). 结论重度妊高征患者血浆EGF水平比正常孕妇低,而其胎盘EGFR表达比正常孕妇强.重度妊高征时的低EGF环境的长期持续使胎盘功能减退,促使了FGR的发生.
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