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The Study of Nimodipine in Treating Pregnancy Induced Hypertension and its Effect on Intraplatelet Free Calcium
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- Author:
- No author available
- Journal Title:
- CHINA JOURNAL OF PERINATAL MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1007-9408.2001.04.002
- Key Word:
- 妊娠并发症,心血管;高血压;尼莫地平;硫酸镁;血小板;钙
Abstract： 目的 探讨尼莫地平(nimodipine NIM)治疗妊娠高血压综合征(简称妊高征)的临床效果及其对血小板细胞内游离钙离子浓度(PF[Ca2+]i)的影响. 方法 将48例中、重度妊高征患者随机分组,给予尼莫地平或硫酸镁治疗,观察治疗前后血压、尿蛋白、PF[Ca2+]i及自觉症状等变化,比较两组妊娠结局. 结果 (1)尼莫地平治疗1/2、1、2 h时血压较用药前明显下降,母心率增快,胎心率无明显变化;(2)使用尼莫地平后PF[Ca2+]i从用药前(188±30) nmol/L降至用药后(153±19) nmol/L(P<0.001), PF[Ca2+]i降低值与平均动脉压下降值之间呈正相关关系(r=0.79, P<0.001); (3)尼莫地平组先兆子患者自觉症状消失时间(1.3±1.5) h,较硫酸镁组(3.2±1.9)h短(P<0.05). 结论 (1)尼莫地平与硫酸镁相比降压效果强且持久,能显著扩张脑血管,改善脑缺氧,快速缓解先兆子患者自觉症状,副作用小;(2)细胞内游离钙水平升高可能是妊高征发病的关键因素.
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