You Position: Home > Paper
The Changes of Plasminogen Activator Inhibitor Type 1,Thrombin Anti-thrombin Ⅲ comlplex and D-dimer in Patients with Preeclampsia
( views:216, downloads:28 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1007-9408.2000.03.001
- Key Word:
- 妊娠并发症,心血管;高血压;纤溶酶原激活物抑制物1;纤维蛋白溶解
Abstract： 目的 测定妊高征患者中的凝固-纤溶因子的变化,探讨胎盘局部凝固-纤溶系统的调节及其在妊高征发病机制中的作用.方法 用放射免疫法测定重度妊高征及正常孕妇的羊水、母体血浆及胎盘组织中纤溶酶原激活物抑制剂1型(PAI-1)、凝血酶抗凝血酶Ⅲ复合物(TAT)及D双聚体(D-dimer)的含量,用人胎盘蜕膜细胞培养系统进行凝血酶负荷试验.结果 在正常妊娠的PAI-1、TAT在羊水中含量分别为(809.2±79.8),(872±214) ng/ml,明显高于母体血浆的(140.9±38.3),(6.1±0.4)ng/ml,胎盘组织中PAI-1含量,蜕膜组织(415.7±39)ng/mg明显高于绒毛组织(93.9±10)ng/mg.在妊高征患者,羊水及胎盘蜕膜组织PAI-1分别为(1 474.5±254.7) ng/ml及(1 164±132) ng/mg蛋白、TAT(132±253.1) ng/ml,D-dimer(132±27.8)ng/ml显著高于正常妊娠.凝血酶可刺激胎盘蜕膜细胞增加PAI-1的产生和分泌,两者存在着量效关系.结论 妊高征中胎盘蜕膜细胞产生和分泌PAI-1水平的增加,使胎盘凝固-纤溶系统发生改变,即凝固亢进,纤溶活性降低.这些改变可能与妊高征发病机制有关.
- [1]V W, Van Hinsbergh,E D, Sprengers,T, Kooistra.Effect of thrombin on the production of plasminogen activators and PA inhibitor-1 by human foreskin microvascular endothelial cells.[J].1987,57(2).
- [2]A, Estellés,J, Gilabert,J, Aznar,etc.Changes in the plasma levels of type 1 and type 2 plasminogen activator inhibitors in normal pregnancy and in patients with severe preeclampsia.[J].1989,74.
- [3]L Gow,D M Campbell,D Ogston.The fibrinolytic system in pre-eclampsia.[J].1984,37(1).
- [4]A, Estellés,J, Gilabert,C, Andrés,etc.Plasminogen activator inhibitors type 1 and type 2 and plasminogen activators in amniotic fluid during pregnancy.[J].1990,64.
- [5]J, Bonnar,L, Daly,B L, Sheppard.Changes in the fibrinolytic system during pregnancy.[J].1990,16.
- [6]M, Hanss,D, Collen.Secretion of tissue-type plasminogen activator and plasminogen activator inhibitor by cultured human endothelial cells: modulation by thrombin, endotoxin, and histamine.[J].1987,109.
- [7]Meiyang Gao,Masao Nakabayashi,Mari Sakura,etc.The Imbalance of Plasminogen Activators and Inhibitor in Preeclampsia[J].1996,22(1).
- [8]HAMAGUCHI MOTOAKI,YAMAMOTO TOSHIHIKO,SUGIYAMA YOUICHI.Production of Prolactin by Cultures of Isolated Cells From Human First-Trimester Decidua[J].1990.
- [9]J, Gilabert,A, Estellés,J, Aznar,etc.Contribution of platelets to increased plasminogen activator inhibitor type 1 in severe preeclampsia.[J].1990,63.