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The Role of Nitric Oxide Synthase in the Genesis of Pregnancy-induced Hypertension and Its Relationship with Estriol
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1007-9408.1999.02.004
- Key Word:
- 一氧化氮合酶;胎盘;游离雌三醇;妊娠高血压综合征
Abstract： 目的 探索一氧化氮合酶(NOS)在妊娠高血压综合征(Pregnancy induced by hypertention,PIH)发病中的作用及其与雌三醇的关系.方法 选取妊娠晚期重度妊高征孕妇32例为研究对象,正常足月妊娠孕妇30例为对照组,以分光光度法测定胎盘组织NOS活性,放射免疫法测定母亲静脉血游离雌三醇(FE3)水平.结果 PIH组胎盘组织NOS活性及母亲静脉血FE3水平明显低于正常对照组(P＜0.01),经相关关系测定,两者之间具正相关关系(r=0.51,P＜0.01).胎盘组织NOS活性与新生儿出生体重之间具正相关关系(r=0.52,P＜0.01).结论 NOS合成障碍在PIH发病中起一定的作用;雌三醇与NOS活性有一定的相关性,提示雌三醇可能是NOS产生的刺激剂;NOS活性与新生儿出生体重具正相关关系,为PIH的防治提供了理论依据.
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