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Association of mutations in basal core promoter and precore region of hepatitis B virus with progress of liver disease

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Author:: No author available

Journal Title:: Chinese Journal of Clinical Infectious Diseases

Issue:: 4

DOI:: 10.3760/cma.j.issn.1674-2397.2012.04.017

Key Word:: 肝炎,乙型;基因;突变;基本核心启动子;前C区;A1762T/G1764A变异;G1896A变异;疾病进展;Hepatitis B;Gene;Mutation;Basal core promoter;Precore;A1762T/G1764A mutation;G1896A mutation;Disease progression

Abstract：乙型肝炎病毒( HBV)感染是我国严重的卫生健康问题,目前大约有1.7亿慢性HBV感染者,约占世界慢性HBV感染者的一半[1].HBV基因组结构为部分环状双链DNA,全长约3.2 kb,其核心启动子对于HBV的复制和形态构成发挥了关键性作用.核心启动子包含基本核心启动子区(basal core promoter,BCP)和上游调控区(upper regulatoryregion,URR),直接引导两种3.5 kb mRNA的转录,即前基因组mRNA( pregenomic RNA,pgRNA)和前CmRNA( precore mRNA,pre-C mRNA).BCP区位于基因组中核苷酸1742～1849位置,目前发现的变异主要有A1762T/G1764A双变异,C1653T、T1753C/A/G、C1766T/T1768A变异等,还发现有缺失和插入变异[2-3].A1762T/G1764A双变异是BCP区最常见的,也是最重要的变异,目前研究较多.

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