Effect of comprehensive hyperbaric oxygen on ulcerative colitis

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YANG Jin-hua(Hyperbaric Oxygen Department, Shenyang No. 5 People’s Hospital, Shenyang 110023, China)
WANG Gang()
Journal Title:
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
Volume 19, Issue 04, 2012
Key Word:
Hyperbaric oxygen;Sulfasalazine;Comprehensive treatment;Ulcerative Colitis

Abstract: Objective To observe the effect of hyperbaric oxygen (HBO) coupled with sulfasalazine on ulcerative colitis,and to investigate safe and effective methods for the treatment of ulcerative colitis.Methods Two hundred and seventy-six cases of ulcerative colitis were randomly divided into the control group receiving only sulfasalazine (135 cases) for 8 weeks and the HBO group (141 cases) treated with HBO combined with sulfasalazine for 8 weeks.Observations were made on the improvement of clinical symptoms and outward appearance under the endoscope in the 2nd,4th and 8th weeks respectively.Results Significant effective rate and total effective rate for the HBO group accounted for 84.4% and 100%,which were significantly higher than those of the control group (44.4% and 76.3% ).There were statistical significance between the two group (P< 0.05 ).Conclusions HBO coupled with sulfasalazine in the treatment of ulcerative colitis could produce quicker and more significant results,and with fewer side-effects.

  • [1]河南省巴柳氮钠临床协作组.巴柳氮钠治疗活动性溃疡性结肠炎的疗效观察.中华消化杂志,2007,27(5):295-298.
  • [2]Haens G.Risks and benefits of biological therapy for inflam matory bowel disease.Gut,2007,56(5):725-732.
  • [3]郑家驹.生物学药物对炎症性肠病治疗的安全性.中华消化杂志,2007,27(9):644-645.
  • [4]中华医学会消化病学分会.对炎症性肠病诊断治疗规范的建议.中华消化杂志,2001,21(4):236-239.
  • [5]中华医学会消化病学分会炎症性肠病协作组.中国炎症性肠病诊断治疗规范的共识意见.中华内科杂志,2008,47(1):73-79.
  • [6]霍丽娟,赵和平.益生菌对实验性结肠炎大鼠肠黏膜细胞因子及核因子-kB表达的影响.中华消化杂志,2007,27(2):95-98.
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