You Position: Home > Paper

Clinical observation on the effect of HBO coupled with mild hypothermia on 88 cases of severe traumatic brain injury

( views:330, downloads:48 )
Author:
No author available
Journal Title:
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
Issue:
4
DOI:
10.3760/cma.j.issn.1009-6906.2012.04.006
Key Word:
高压氧;亚低温;重型颅脑外伤;并发症;Hyperbaric oxygen;Mild hypothermia;Severe traumatic brain injury;Complications

Abstract: Objective To explore the therapeutic effect of HBO coupled with mild hypothermia on 88cases of severe traumatic brain injury and to study the effect of HBO on complications.Methods Two hundred and twenty-two cases of severe traumatic brain injury were divided into the HBO therapy coupled with mild hypothermia group ( or the combined group ),the mild hypothermia therapy group ( or the mild hypothermia group),and the HBO therapy group ( or the HBO group).Mild hypothermia treatment time was 1 to 11 days,after the onset of severe traumatic brain injury.Both the combined group and the HBO groups were given HBO therapy.Following treatment,the rate of complications,the therapeutic effects,the scores of Glasgow Coma Scale (GCS) after 3 months of treatment,the scores of Glasgow Outcome Scale (GOS) and scores of long-term Life Quality Assessment Scale after 6 months of treatment were compared and analyzed.Results The rate of pulmonary infection for the mild hypothermia group was 41.7% and the rate of renal dysfunction accounted for 25.0%,and statistical differences could be seen,when they were compared with those of the other two groups ( P < 0.05 ).For the combined group,significant therapeutic effect accounted for 64.8%,with a total effective rate of 93.2%,and statistical differences could be seen,when they were compared with those of the other 2groups (P < 0.01 ).After 3 months of treatment,the scores of GCS and GOS of the combined group were significantly higher than those of the other 2 groups (P <0.05 or P <0.01 ).After 6 months of treatment,the scores of long-term Life Quality Assessment Scale of the combined group were also significantly higher than those of the other 2 groups ( P < 0.05 or P < 0.01 ).Conclusions HBO therapy combined with mild hypothermia could significantly decrease the morbidity and mortality,obviously improve the neurological function and considerably improve prognosis of patients with severe traumatic brain injury.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn