Abstract： Objective To investigate related factors affecting the development of depression in uremia patients.Methods Research subjects were 120 uremia patients hospitalized in our hospital from January 2007 to May 2011.At the same time,100 non-uremia patients were selected as control.Symptoms of depression were measured with the self-rating depression scale (SDS).Results When a comparison was made between the research group and the control group,it was found that uremia patients had a significantly higher incidence of depression than the non-uremia patients.Female uremia patients,having an age of over 60 years old and higher education level,receiving hemodialysis,with little understanding of prognosis and long course of disease,and without public medical care,were more susceptible to depression.Conclusions In the course of treatment,great attention should be paid not only to the treatment of uremia itself,but also to the mental status of the patients,and positive psychological intervention should be made for better treatment results.