Abstract： Objective To investigate the changes and meanings of intestinal immune function in rats with open celiac seawater immersion wounds. Methods The rats model of open celiac seawater immersion wounds in rats was built with fifty male Wistar rats which were randomly divided into five groups; celiac seawater immersion group with abdominal open injury (group A), abdominal open injury group without seawater immersion (group B) , abdominal seawater immersion group without abdominal open injury ( group C) , celiac physiological saline immersion group with abdominal open injury (group D) and normal control group ( group E) to observe the levels of SIgA in intestinal content; IgA, LPS, TNF-αand IL-6 in plasma; BT through quantitative bacterial culture in plasma, liver and MLN in each group, and to observe injury scoring by HE staining intestinal mucosa. Results the levels of SIgA in intestinal content and IgA in plasma decreased significantly in group A. The levels of LPS, TNF-αand IL-6 in plasma increased significantly in group A.The bacterial translocation increased significantly in plasma, liver and MLN in group A( P < 0.05 or P < 0.01). By HE staining intestinal mucosa, it was observed that different degrees of injuries occurred to the small intestine (P <0. 05 or P < 0. 01). Conclusions Celiac seawater immersion can damage intestinal mucosal immune function in rats with open celiac seawater immersion wounds significantly, and it also relates closely with endotoxemia and BT. The release of quantity of cytokine and intestinal mucosal barrier injury are important reasons for intestinal immune function injury.