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Changes of L-arginine/NO synthase/nitric oxide pathway of platelets in sailors of submarine
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1009-6906.2007.06.001
- Key Word:
- 潜艇艇员;血小板;L-精氨酸;一氧化氮合酶;一氧化氮
Abstract： 目的 观察潜艇人员血小板L-精氨酸(L-Arg)转运动力学,一氧化氮合酶(NOS)活性,血浆、血小板一氧化氮(NO)含量,探讨潜艇人员内皮功能变化,为预防心血管疾病提供依椐.方法 48名健康男性潜艇人员及18名健康男性陆勤人员为对照者,静脉血制备血小板血浆,用放射性同位素标记法测定3H-L-Arg 在血小板转运中的动力学特征;测定血小板NO产物--亚硝酸盐量及NOS活性.结果 潜艇艇员血小板L-Arg转运功能明显减低,L-Arg最大转运速度(Vmax)较同期陆勤人员低31.0%(P＜0.01),米氏常数(Km)值增加11.4%(P＜0.01),NOS活性较陆勤组减少51.1%(P＜0.01),血浆及血小板NO-2水平分别低于陆勤组35.2%(P＜0.01)、82.8%(P＜0.01).结论 由于特殊环境,潜艇艇员存在血小板L-Arg/NOS/NO系统功能异常,L-Arg转运障碍,NOS活性显著减低,血浆及血小板NO生成明显减少,提示潜艇艇员有血管内皮功能受损征象,其特殊职业可影响心血管疾病发病学基础.
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