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The effect of hyperbaric oxygen on kidney dysfunction caused by rat hind limb ischemia/reperfusion

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
Issue:
5
DOI:
10.3760/cma.j.issn.1009-6906.2006.05.002
Key Word:
下肢;缺血再灌注;高压氧;激光多普勒;血小板膜糖蛋白

Abstract: 目的 探讨高压氧(HBO)对减轻大鼠肢体缺血再灌注(I/R)致肾脏损伤的作用及机制.方法 复制I2h/R1h模型,分为3组,即A组(假手术组)、B组(I/R模型组)、C组(HBO治疗组).观察肾脏微血流变化;对肾脏组织行电镜病理检查;记录血清CD31、CD61平均荧光强度和CD62p的阳性率.结果 与B组比较,C组肾脏微血流速度明显升高,差异有统计学意义著(P<0.05).与B组比,C组肾脏组织病理改变较轻.与A组比较,B组CD31、CD61及CD62p均有升高,其中CD31和CD62p升高显著(P<0.05);与B组比较,C组CD31、CD61及CD62p均有下降,其中CD31和CD62p下降尤为显著(P<0.05).结论 早期行HBO处理可显著减少急性下肢I/R大鼠模型血小板膜糖蛋白CD31和CD62p的表达,从而有助于减轻下肢I/R继发肾脏损伤.

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