You Position: Home > Paper
Effect of gamma irradiation at low dose-rate on the level of IL-12 and IL-10 in the plasma of mice
( views:238, downloads:4 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-6906.2006.03.003
- Key Word:
- 60Co-γ射线;低剂量率;低剂量;白介素IL-12;白介素IL-10;免疫学;辐射
Abstract： 目的研究低剂量电离辐射对小鼠免疫系统影响的剂量率效应.方法以60Co-γ射线为辐照源,低、中和高3个辐射剂量(0.075、0.5、2.0Gy),恒定剂量率(0.5 mGy/min)全身一次性照射小鼠,ELISA检测照射4 h后血浆IL-12和IL-10的含量.结果低、中剂量照射后,血浆中IL-12、IL-10和IL-12/IL-10出现程度几乎相同地下降;但高剂量照射后,IL-12进一步显著下降,而IL-10上升至对照组水平,IL-12/IL-10比值进一步下降.结论恒定0.5 mGy/min剂量率的60Co-γ射线照射可损伤机体免疫功能,在0.075～0.5Gy剂量范围内损伤轻微,在2.0 Gy时损伤明显,表明低剂量率电离辐射对免疫系统具有损伤作用.
- [1]林永丽,高军.低剂量辐射对机体免疫效应的研究现状[J].2004,(1).
- [2]刘树铮.辐射免疫学中的剂量效应关系[J].2002,(6).
- [3]刘晓冬,刘树铮,马淑梅,等.低剂量X射线全身照射后小鼠IL-10和 IL-12的反向变化[J].2001,(4).
- [4]竺青,高军,龙建秋,等.低剂量60Co-γ射线75mGy全身照射对小鼠血浆中IL-12和IL-10的影响[J].2005,(2).
- [5]R Kallio,H.-M Surcel,A Bloigu,etc.Balance between interleukin-10 and interleukin-12 in adult cancer patients with or without infections[J].2001,37(7).
- [6]S Z, Liu,S Z, Jin,X D, Liu,etc.Role of CD28/B7 costimulation and IL-12/IL-10 interaction in the radiation-induced immune changes.[J].2001,2.
- [7]Jimbow K,Kondo S.Dose-dependent induction of IL-12 but not IL-10 from human keratinocytes after exposure to ultraviolet light A.[J].1998,177(3).
- [8]Laurens P. Koopman,Huub Savelkoul,Inesz J. Van Benten,etc.Increased serum IL-10/IL-12 ratio in wheezing infants[J].2003,14(2).
- [9]Godekmerdan A,Ozden M,Gursu MF,etc.Diminished cellular and humoral immunity in workers occupationally exposed to low levels of ionizing radiation.[J].2004,35(4).
- [10]Cohen Bernard L..Cancer Risk from Low-Level Radiation[J].2002.