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Hyperbaric therapy suppresses endolymphatic hydrops in guinea pigs
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-6906.2004.04.002
- Key Word:
- 内淋巴积水;组织学;听觉脑干电反应;耳蜗电图;压力治疗
Abstract： 目的探讨中耳加压治疗是否可抑制豚鼠内淋巴积水.方法 42只豚鼠随机分为4组:对照组10只,双耳未手术;32只豚鼠右耳制备内淋巴积水的动物模型:积水4周组10只,积水8周组10只,加压组12只.加压组豚鼠在术后第5周起在压力舱内进行加压治疗,共3周.观察4组动物耳蜗形态和功能的变化.结果加压组右耳70 dB SPL-SP/AP值、最大中阶面积(SMA)比率(分别0.29±0.09,2.23±0.20)与相同生存期的积水8周组(分别为0.69±0.15,4.01±0.52)相比显著减小(P＜0.05),而与积水4周组(分别为0.29±0.13,2.22±0.20)差异不显著(P＞0.05).加压组右耳听觉脑干电反应(ABR)听阈[(36.67±14.30) dB SPL]低于积水8周组[(44.00±14.30) dB SPL],但差别无统计学意义(P＞0.05).结论加压治疗可显著抑制内淋巴积水的发展,并改善耳蜗功能.为梅尼埃病的治疗寻找一种无创伤性方法--加压治疗提供实验依据.
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